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First published on July 10, 2006, doi:10.1177/0363546506289882
This version was published on November 1, 2006
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The American Journal of Sports Medicine 34:1824-1831 (2006)
© 2006 American Orthopaedic Society for Sports Medicine

Effects of Calcified Cartilage on Healing of Chondral Defects Treated With Microfracture in Horses

David D. Frisbie, DVM, PhD, DACVS*,{dagger}, Sophie Morisset, DVM, MSc, PhD, DACVS{ddagger}, Charles P. Ho, PhD, MD§, William G. Rodkey, DVM||, J. Richard Steadman, MD|| and C. Wayne McIlwraith, BVSc, PhD, DACVS{dagger}

From the {dagger} Equine Orthopaedic Research Center, Colorado State University, Fort Collins, Colorado, {ddagger} Faculté de Médecine, Vétérinaire Université de Montréal, Québec, Canada, § National Orthopedic Imaging Associates, California Advanced Imaging, Atherton, California, and || Steadman-Hawkins Sports Medicine Foundation, Vail, Colorado

* Address correspondence to David D. Frisbie, DVM, PhD, DACVS, Equine Orthopaedic Research Center, Colorado State University, 300 West Drake Road, Fort Collins, CO 80523 (e-mail: lbierman{at}lamar.colostate.edu).

Background: Microfracture of full-thickness articular defects has been shown to significantly enhance the amount of repair tissue. However, there is a suggestion that leaving calcified cartilage inhibits this repair response.

Hypothesis: Removal of the calcified cartilage with retention of subchondral bone enhances the amount of attachment of the repair tissue compared with retention of the calcified cartilage layer.

Study Design: Controlled laboratory study.

Methods: There were 1-cm2 articular cartilage defects made in 12 skeletally mature horses on the axial weightbearing portion of both medial femoral condyles. Using a custom measuring device and direct arthroscopic observation of the subchondral bone beneath the calcified cartilage layer, the authors removed the calcified cartilage from 1 defect of each horse. The repair was assessed with arthroscopy, clinical examination, radiographic and magnetic resonance imaging examinations, biopsy at 4 months, gross and histopathologic examinations at 12 months, as well as mRNA and immunohistochemical evaluations.

Results: Removal of calcified cartilage with retention of the subchondral bone plate increased the overall repair tissue as assessed by arthroscopic (4 months) and gross evaluation (12 months). An increase in the level of the subchondral bone was also observed with removal of the calcified cartilage layer. The clinical pain, radiographic examinations, magnetic resonance imaging evaluations, histologic character, matrix proteins, or mRNA expression do not appear to differ based on level of defect debridement.

Clinical Relevance: Removal of the calcified cartilage layer appears to provide optimal amount and attachment of repair tissue. Therefore, close arthroscopic visualization is recommended for debridement of clinical lesions to ensure removal of the calcified cartilage layer.

Key Words: horse • microfracture • calcified cartilage • cartilage resurfacing • cartilage debridement • joint




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