| HOME | HELP | CONTACT US | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Sign In to gain access to subscriptions and/or personal tools.
|
|
|
|||||||
Sign In to gain access to subscriptions and/or personal tools. |
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
From the Section for Orthopaedics and Sports Medicine, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linköping, Sweden
* Address correspondence to Per Aspenberg, MD, PhD, Section for Orthopaedics and Sports Medicine, Department of Neuroscience and Locomotion, Faculty of Health Sciences, SE-581 85 Linköping, Sweden (e-mail: per.aspenberg{at}inr.liu.se).
Background: Cyclooxygenase-2 inhibitors inhibit bone repair.
Hypothesis: Cyclooxygenase inhibitors might also have a negative effect on early tendon repair, although a positive effect on late tendon repair previously has been shown.
Study Design: Controlled laboratory study.
Methods: Achilles tendon transection was performed on 80 rats. Sixty rats were given daily intramuscular injections of either parecoxib (6.4 mg/kg body weight) or saline for the first 5 days after surgery and sacrificed either at 8 or 14 days. The remaining 20 rats were given intramuscular parecoxib or saline injections from day 6 until sacrifice at 14 days.
Results: At 8 days, early parecoxib treatment caused a 27% decrease in force at failure (P = .007), a 25% decrease in maximum stress (P = .01), and a 31% decrease in energy uptake (P = .05). Stiffness and transverse area were not significantly affected. At 14 days, early parecoxib treatment caused a decrease in stiffness (P = .004). In contrast to early treatment, late parecoxib treatment caused a 16% decrease in cross-sectional area (P = .03) and a 29% increase in maximum stress (P = .04).
Conclusions: During early tendon repair, a cyclooxygenase-2 inhibitor had a detrimental effect. During remodelling, however, inflammation appears to have a negative influence, and cyclooxygenase-2 inhibitors might be of value.
Clinical Relevance: The results suggest that cyclooxygenase-2 inhibitors should be used with care in the early period after tendon injury.
Key Words: nonsteroidal anti-inflammatory drug (NSAID) • tendon repair • ligament • rat • remodeling
This article has been cited by other articles:
|
|
 |
|
  P Tscholl, A Junge, and J Dvorak The use of medication and nutritional supplements during FIFA World Cups 2002 and 2006 Br. J. Sports Med., September 1, 2008; 42(9): 725 - 730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. Ferry, L. E. Dahners, H. M. Afshari, and P. S. Weinhold The Effects of Common Anti-Inflammatory Drugs on the Healing Rat Patellar Tendon Am. J. Sports Med., August 1, 2007; 35(8): 1326 - 1333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Simon and J. P. O'Connor Dose and Time-Dependent Effects of Cyclooxygenase-2 Inhibition on Fracture-Healing J. Bone Joint Surg. Am., March 1, 2007; 89(3): 500 - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Cohen, S. Kawamura, J. R. Ehteshami, and S. A. Rodeo Indomethacin and Celecoxib Impair Rotator Cuff Tendon-to-Bone Healing Am. J. Sports Med., March 1, 2006; 34(3): 362 - 369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Rubino III and M. D. Miller What's New in Sports Medicine J. Bone Joint Surg. Am., February 1, 2006; 88(2): 457 - 468. [Full Text] [PDF]
|
|
|
|
|
|
Evidence based journal watch Br. J. Sports Med., June 1, 2005; 39(6): 371 - 372. [Full Text] [PDF]
|
|
| HOME | HELP | CONTACT US | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
