HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:
Sign In to gain access to subscriptions and/or personal tools.

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Request Reprints Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jackson, D. W. Articles by Gendler, E. Search for Related Content PubMed Articles by Jackson, D. W. Articles by Gendler, E.

Biologic Remodeling after Anterior Cruciate Ligament Reconstruction Using a Collagen Matrix Derived from Demineralized Bone

An Experimental Study in the Goat Model

Orthopaedic Research Institute at the Southern California Center for Sports Medicine and Long Beach Memorial Medical Center, Long Beach

Timothy M. Simon, MS

Orthopaedic Research Institute at the Southern California Center for Sports Medicine and Long Beach Memorial Medical Center, Long Beach

Wylie Lowery, MD

Orthopaedic Research Institute at the Southern California Center for Sports Medicine and Long Beach Memorial Medical Center, Long Beach

El Gendler, MD, PhD

Pacific Coast Tissue Bank, Los Angeles, California

A matrix of demineralized cortical bone was used to reconstruct the anterior cruciate ligament in the goat model. This graft underwent considerable site-specific remodeling and transformation from a Haversian sys tem at time zero into a ligament-like structure at 1 year. This transformation included new bone formation filling the osseous tunnels and replacing the demineralized matrix, development of a ligament-like transition zone within the graft, and ligamentous collagen orientation with crimp in the intraarticular portion of the graft. One year after surgery, the mean anterior-posterior trans lation in the reconstructed stifle joints at 30 N of tibial loading was 2.1 ± 0.4 mm (±SEM). The mean ultimate force to failure for the reconstructed ligament at 1 year was 474 ± 146 N compared with the time-zero (initial) strength of the matrix of 73 ± 9 N. The cellular repopu lation of the graft had no associated inflammatory cells. The potential clinical significance of these findings in cludes 1) replacement of a collagen matrix with bone within the osseous tunnels, 2) establishment of a more physiologic fibrocartilage transition at the graft inser tion site, 3) the time-zero structural properties of a collagen matrix increasing to more desired values with biologic remodeling, and 4) a sterile biologic allograft with essentially no long-term inflammatory response.

This article has been cited by other articles:

				O. Gurevitch, B. G. S. Kurkalli, T. Prigozhina, J. Kasir, A. Gaft, and S. Slavin Reconstruction of Cartilage, Bone, and Hematopoietic Microenvironment with Demineralized Bone Matrix and Bone Marrow Cells Stem Cells, September 1, 2003; 21(5): 588 - 597. [Abstract] [Full Text] [PDF]

				F. H. Fu, C. H. Bennett, C. B. Ma, J. Menetrey, and C. Lattermann Current Trends in Anterior Cruciate Ligament Reconstruction: Part II. Operative Procedures and Clinical Correlations Am. J. Sports Med., January 1, 2000; 28(1): 124 - 130. [Abstract] [Full Text] [PDF]