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Department of Orthopaedic Surgery, University of Southern California School of Medicine, Los Angeles, California
Department of Orthopaedic Surgery, University of Southern California School of Medicine, Los Angeles, California
Department of Orthopaedic Surgery, University of Southern California School of Medicine, Los Angeles, California
Department of Orthopaedic Surgery, University of Southern California School of Medicine, Los Angeles, California
Department of Orthopaedic Surgery, University of Southern California School of Medicine, Los Angeles, California
Sixty 10-mm bone-patellar tendon-bone allografts from young human donors were placed into four test groups, a control fresh-frozen group and three fresh-frozen ir radiated groups. The irradiated groups were exposed to 2.0, 3.0, or 4.0 Mrad of gamma irradiation. The speci mens were tested to tensile failure. The initial biome chanical strength of fresh-frozen allografts was reduced up to 15% when compared with fresh-frozen controls after 2.0 Mrad of irradiation. Maximum force, strain en ergy, modulus, and maximum stress demonstrated a statistically significant reduction after 2.0 Mrad of irra diation (P< 0.01). Stiffness, elongation, and strain were reduced but not with statistical significance. A 10% to 24% and 19% to 46% reduction in all biomechanical properties were found after 3.0 (P < 0.005) and 4.0 (P < 0.0005) Mrad of irradiation, respectively. After irra diation with a 4.0 Mrad dose, the ultimate load was be low that of reported values for the human anterior cru ciate ligament. It is clinically important to observe and document changes in human ligaments that result from currently used doses of gamma irradiation. The results from this study provide important information regarding the initial biomechanical properties of fresh-frozen hu man bone-patellar tendon-bone allografts after bacte rial sterilization with gamma irradiation. The current ac cepted dose for sterilization is between 1.5 and 2.5 Mrad. There appeared to be a dose-dependent effect of irradiation on all the biomechanical parameters studied. Four of seven parameters were found to be reduced after 2.0 Mrad of irradiation. Reductions were found in all parameters after 3.0 and 4.0 Mrad of irradiation.
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